Ongoing Research: PCP BioCyanium and Plasmons
Our ongoing B11 Micro-Tecnology research is focused on understanding the role of Surface Plasmon Resonance (SPR) and plasmonic effects in the activation of our PCP BioCyanium, a key component in our therapeutic approach. Central to this research are the quantum-mechanical properties developed by B11 Micro-Tecnology processes. By investigating how these phenomena contribute to the generation of oxidative stress, we aim to uncover new insights into targeted therapies that utilise PCP BioCyanium to improve cellular health and potentially enhance treatment efficacy. This research is actively shaping the future of our advanced therapies, leveraging the unique interaction between light, nanomaterials, and cellular processes.
The Role of B11 Micro-Tecnology
Our B11 Micro-Technology is a key driver behind the advancements in the development of PCP BioCyanium. This cutting-edge technology allows us to precisely manipulate and enhance the properties of PCP BioCyanium at a molecular level, optimising its interaction with light and cellular structures. By leveraging B11 Micro-Tecnology , we are able to fine-tune PCP BioCyanium’s behavior, ensuring its priority uptake by target cells and maximising its therapeutic potential. This technological breakthrough is integral to our ongoing research, enabling us to push the boundaries of targeted therapy and enhance treatment efficacy.
The Role of Surface Plasmon Resonance (SPR) and Plasmons in PCP BioCyanium-Mediated Oxidative Stress
PCP BioCyanium, our proprietary technology-based, naturally derived and scientifically enhanced molecule, leverages the principles of Surface Plasmon Resonance (SPR) and plasmonic effects to induce targeted oxidative stress in cancer cells when activated by near-infrared (NIR) light.
Understanding Surface Plasmon Resonance (SPR) and Plasmons
SPR refers to the collective oscillation of free electrons on the surface of a conductive material in response to incident light. This phenomenon occurs when the frequency of incident photons matches the natural frequency of surface electrons, leading to a resonance effect. The oscillating electrons, known as plasmons, can be excited by specific wavelengths of light, particularly in the NIR range, which is advantageous for deep tissue penetration in biological systems.
Mechanism of Oxidative Stress Induction
When PCP BioCyanium accumulates in cancer cells and is exposed to NIR light, the following sequence occurs:
- Plasmon Excitation: The NIR light excites the plasmons on the surface of PCP BioCyanium, causing them to oscillate.
- Energy Conversion: The energy from these oscillations is transferred to the surrounding medium, leading to localised heating.
- Reactive Oxygen Species (ROS) Generation: The elevated temperature and energy facilitate the production of ROS, including singlet oxygen and free radicals, within the cancer cells.
- Oxidative Stress: The accumulation of ROS overwhelms the cell's antioxidant defences, resulting in oxidative damage to cellular components such as lipids, proteins, and DNA.
- Cell Death: This oxidative damage triggers apoptosis, or programmed cell death, selectively eliminating cancer cells.
Role of Mechanical Oscillations and Localised Heating
The mechanical oscillations of plasmons not only facilitate energy transfer but also contribute to localised heating. This localised increase in temperature can enhance the production of ROS, thereby amplifying the therapeutic effect. The localised heating effect is particularly significant in photothermal therapy, where the temperature rise induced by plasmonic nanoparticles can lead to cell death through hyperthermia. Studies have demonstrated that some materials can convert NIR light into heat, resulting in localised heating that induces cell death in cancer cells.
Read More or Contact Us for more information.
